Clopidogrel before coronary artery surgery: bleeding or no bleeding?
نویسندگان
چکیده
منابع مشابه
Bleeding post coronary artery bypass surgery. Clopidogrel--cure or culprit?
BACKGROUND Clopidogrel, in addition to aspirin, has become a common treatment of acute coronary syndrome and for stent thrombosis prevention, when given before percutaneous transluminal coronary angioplasty. However, some patients turn out to have surgical coronary artery disease and are sent for coronary artery bypass grafting (CABG) where the irreversible effect of aspirin and clopidogrel on ...
متن کاملPlatelet Function Testing and Prediction of Bleeding in Patients Exposed to Clopidogrel Undergoing Coronary Artery Surgery.
We read with great interest the recently published study by Reed et al.1 The authors conducted a proof-of-principle, prospective, observational pilot study of 39 clopidogreltreated patients scheduled for on-pump coronary artery surgery (CAS).1 Briefly, the authors found that the VerifyNow P2Y12 assay (Accumetrics, San Diego, CA) can predict bleeding within the first 24 hours after CAS.1 This pi...
متن کاملBleeding outcomes associated with coronary artery bypass graft surgery and recent clopidogrel exposure.
BACKGROUND Guidelines recommend discontinuing clopidogrel for at least 5 days before elective coronary artery bypass graft surgery (CABG) to limit blood transfusions and for at least 24 hours before urgent CABG to reduce major bleeding complications. Studies have produced conflicting results regarding whether recent exposure to clopidogrel increases bleeding, the need for intraoperative and pos...
متن کاملCoronary artery bypass grafting-related bleeding complications in real-life acute coronary syndrome patients treated with clopidogrel or ticagrelor.
OBJECTIVES Ticagrelor reduces thrombotic events compared with clopidogrel in patients with acute coronary syndrome, but may also increase bleeding complications. Coronary artery bypass grafting (CABG)-related bleeding complications have not previously been compared in clopidogrel and ticagrelor-treated patients outside the controlled environment of clinical trials. METHODS Four hundred and fi...
متن کاملClopidogrel-related refractory bleeding after coronary artery bypass graft surgery: a rationale for the use of coagulation factor concentrates?
Clopidogrel, an irreversible ADP-receptor antagonist, inhibits platelet aggregation mediated by reduced activation of glycoprotein receptor IIb/IIIa. Clopidogrel in combination with aspirin has been shown to be superior to aspirin alone for treating unstable angina, but clopidogrel recipients have shown increases in blood loss, transfusion requirements, and rate of reoperation after cardiac sur...
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ژورنال
عنوان ژورنال: European Journal of Cardio-Thoracic Surgery
سال: 2004
ISSN: 1010-7940
DOI: 10.1016/j.ejcts.2004.04.013